Svein Řie, Ph.D. Dean, College of Pharmacy Professor Pharmaceutical and Biomedical Sciences Office: Room 100, R.C. Wilson Pharmacy Phone: (706) 542-1914 E-mail: soie@rx.uga.edu

Biosketch

Cand. Pharm, School of Pharmacy	University of Oslo	Oslo, Norway	1966
Ph.D., Pharmaceutics, School of Pharmacy	State University of New York	Buffalo N.Y.	1975
Postdoctoral Fellow Pharmaceutics, School of Pharmacy	State University of New York	Buffalo N.Y.	1975
Assistant Professor	Depts of Biopharmaceutical Sciences and Pharmaceutical Chemistry	UCSF	1976-1982
Associate Professor	Depts of Biopharmaceutical Sciences and Pharmaceutical Chemistry	UCSF	1982-1990
Professor	Depts of Biopharmaceutical Sciences and Pharmaceutical Chemistry	UCSF	1990-1999
Dean	College of Pharmacy, University of Georgia	Athens, GA	2000-present
Professor	Dept of Pharmaceutical and Biomedical Sciences, UGA	Athens, GA	2000-present

Honors and Awards
1971-73 Fellowship, Norwegian Institute for Natural Sciences
1983 Long Award for Excellence in Teaching, School of Pharmacy, UCSF
1992 University of Helsinki Medal, University of Helsinki, Finland.
1992 Third Annual Per Finholt Lecture, University of Oslo, Norway

Research Interests
Strategies for Increased Oral Absorption and Drug Targeting.
A number of pharmacologically active proteins and peptides have recently been identified for use as potential drugs. Two factors in particular handicap these compounds from being clinically active: 1) poor absorption across membranes and 2) instability when administered per os. Clearly, the ability to increase the transfer of these compounds across various membranes, particularly the gastrointestinal wall, would make a significant contribution to optimizing this form of drug therapy and our research interest is focused on exploring various transport mechanisms to develop a means to transport these poorly absorbed compounds per os.

Selectively targeting specific cell types, as a novel drug delivery approach, requires identification of the unique characteristics of the designated target cells. Mechanisms for developing delivery systems that will associate with for individual cell types followed by cellular uptake of the delivery system containing the drug or local release of the associated drugs are being explored.

Biochemical and Clinical Factors Influencing Disposition and Pharmacologic Activity of Drugs.
A number of factors are known to affect the disposition and pharmacologic activity of drugs. These include disease state, genetic and environmental factors, anthropomorphic and physiologic conditions, proteins and protein binding. Current interest focuses on effect of the activation of the acute phase response in disease and trauma on drug disposition.

Representative Publications

• Use of the intestinal bile acid carrier for the transport of HIV-1 protease inhibitors. M. Kĺgedahl, P.W. Swaan, M. Tang, C. Redemann, C. Craik, F.C. Szoka Jr. and S. Řie, Pharmaceutical Research 14: 176-180, 1997
  
• Enhanced transepithelial transport of peptides by conjugation to cholic acid. P.W. Swaan , K.M. Hillgren, F.C. Szoka Jr. and S. Řie, Bioconjugate Chemistry, 8: 520-525, 1997
  
• Mapping the binding site of the hepatic bile acid carrier using the CoMFA technique. P.W. Swaan, F.C. Szoka Jr., and S. Řie, Computer-Aided Molecular Design, 11: 581-588, 1997
  
• Clinical pharmacology of moclobemide during chronic administration of high doses to healthy subjects. J. Dingemanse, N. Wood, T. Guentert, S. Řie, M. Ouwerkerk, and R. Amrein, Psychopharmacology, 140:164-172, 1998
  
• VLDL-resembling phospholipid-submicron emulsion for cholesterol-based drug targeting. M. Shawer, P. Greenspan, S. Řie, and D.R. Lu, J Pharm Sci, 91:1405-1413, 2002
  
• Sequential first-pass metabolism of nortilidine: The active metabolite of the synthetic opioid drug tilidine. J.P. Hajda, E. Jähnchen, S. Řie, and D. Trenk, J Clin Pharmacol 42: 1-5, 2002
  
• Synthesis, preformulation and liposomal formulation of cholesteryl carborene esters with various fatty chains. F. Alanazi, H. Li, D.S. Halpern, S. Řie, and D.R. Lu, International J. Pharmaceutics, 255: 189-197, 2003
  
• In vitro gene transfection to glioma cells using a novel and less cytotoxic artificial lipoprotein delivery system. G. Pan, M. Shawer, S. Řie, and D.R. Lu, Pharm. Research, 20: 738-744, 2003